Pair Name	Resveratrol, Talazoparib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	ATG5	hsa9474
	Up-regulation	Expression	ATG7	hsa10533
	Down-regulation	Expression	HR	hsa55806
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Down-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Expression	MAPK14	hsa1432
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vivo Model	Exponentially growing MCF-7 cells (5×10⁶ per mouse) were injected subcutaneously into the flank of 6 weeks old female SCID mice (weighing 25-35 g, 5 mice per group).
Result	Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux